第49届圣安东尼奥乳腺癌研讨会(SABCS 2026)将于当地时间2026年12月8-11日在美国得克萨斯州圣安东尼奥举行。作为乳腺癌领域的顶级盛会,SABCS聚焦乳腺癌生物学、病因、预防、诊断及治疗前沿,促进临床、转化与基础研究的深度融合,为全球科研人员提供交流协作与专业成长的平台。日前,SABCS官网已披露本届大会摘要标题。
编者按:第49届圣安东尼奥乳腺癌研讨会(SABCS 2026)将于当地时间2026年12月8-11日在美国得克萨斯州圣安东尼奥举行。作为乳腺癌领域的顶级盛会,SABCS聚焦乳腺癌生物学、病因、预防、诊断及治疗前沿,促进临床、转化与基础研究的深度融合,为全球科研人员提供交流协作与专业成长的平台。日前,SABCS官网已披露本届大会摘要标题。
肿瘤瞭望特整理会议第二天(12月9日)精彩内容,涵盖焦点壁报、全体大会、案例讨论、职业发展论坛、特别会议、教育专场、壁报展示及Mini口头报告等,并将并将全体大会1(General Session 1)及Mini口头报告(Rapid Fire 3和Rapid Fire 4)摘要题目进行整理,以便读者快速了解会议动态,敬请关注后续详细报道!
四场焦点壁报专场:1、焦点壁报1:乳腺癌治疗反应的空间与免疫驱动因素;2、焦点壁报2:中枢神经系统(CNS);3、焦点壁报3:HER2 阳性乳腺癌;4、焦点壁报4:局部区域治疗的个体化与降阶梯治疗。
两场全体大会专场:1、开幕致辞;2、全体大会1。
一场大会特邀讲座:SABCS 2026 主题演讲:超级融合——人工智能、遗传学、生物技术与人类健康及癌症治疗的未来
一场案例讨论:临床病例讨论。
一场职业发展论坛:在繁重职业与照护责任之间寻求平衡。
一场获奖讲座:“明日之星”获奖演讲。
两场壁报展示:1、Poster Session 1;2、Poster Session 2。
两场特别会议:1、特别专场4:人工智能在乳腺癌中的应用——从科学发现到临床转化;2、特别专场8:小叶乳腺癌——并非罕见病。
一场辩论专场:临床争议:颠覆早期乳腺癌的诊疗范式——小肿瘤的重大选择。
一场前沿进展:前沿进展1:治疗优化——早期乳腺癌的基因组学与动态监测。
五场教育专场:1、教育专场10:压力、社会决定因素与乳腺癌——解析风险与预后之间的作用路径;2、教育专场11:肿瘤微环境(TME)中被遗忘的细胞;3、教育专场7:三阴性乳腺癌的争议探讨;4、教育专场8:精准治疗的错觉——激素受体阳性转移性乳腺癌中未进行分子筛选的治疗;5、教育专场9:靶向蛋白降解——新型策略与早期临床探索。
两场Mini口头报告:1、Rapid Fire 3;2、Rapid Fire 4。
专场:General Session 1
时间:12月9日9:30 AM–11:45 AM CST
地点:Hall 1
摘要号:GS1-1
External Validation of a Causal Multi-Modal AI Model for Prognosis and Chemotherapy Benefit in Node-Negative HR+/HER2- Breast Cancer Patients: Analysis of TAILORx
淋巴结阴性HR+/HER2-乳腺癌患者预后及化疗获益的因果多模态AI模型的外部验证:TAILORx研究分析
讲者:Nancy Chan, NYU Langone Health, New York, NY
摘要号:GS1-2
Blinded validation of a causal multi-modal AI model in postmenopausal, node-positive, HR+ breast cancer: analysis of SWOG-8814
因果多模态AI模型在绝经后、淋巴结阳性、HR+乳腺癌患者中的盲法验证:SWOG-8814研究分析
讲者:Alastair M Thompson, Baylor College of Medicine, Houston, TX
摘要号:GS1-4
Efficacy results of the SWOG-S1418 / NRG Oncology BR006 randomized Phase III trial evaluating adjuvant Pembrolizumab for triple negative breast cancer with residual disease after neoadjuvant chemotherapy.
评估帕博利珠单抗用于三阴性乳腺癌新辅助化疗后残留病灶辅助治疗的SWOG-S1418 /NRG Oncology BR006随机III期研究的疗效结果
讲者:Lajos Pusztai, Yale School of Medicine, New Haven, CT
摘要号:GS1-5
Neoadjuvant Famitinib in combine with Camrelizumab and chemotherapy in Triple Negative breast cancer (BCTOP-T-N01): a multicentre, randomized, phase 3 trial
法米替尼联合卡瑞利珠单抗及化疗用于三阴性乳腺癌新辅助治疗(BCTOP-T-N01):一项多中心、随机、3期临床研究
讲者:李俊杰(复旦大学附属肿瘤医院)
摘要号:GS1-6
Results of phase II NeoTRACT trial: Neoadjuvant tumor infiltrating lymphocyte- and response-adapted chemoimmunotherapy for triple-negative breast cancer (TNBC)
II期NeoTRACT研究结果:基于肿瘤浸润淋巴细胞及治疗反应指导的三阴性乳腺癌(TNBC)新辅助化疗联合免疫治疗
讲者:Priyanka Sharma, University of Kansas Medical Center, Westwood, KS
摘要号:GS1-8
First-line sacituzumab tirumotecan (sac-TMT) vs chemotherapy in unresectable recurrent or metastatic triple-negative breast cancer (TNBC) with PD-L1 CPS <10 or prior early-stage PD-(L)1 exposure: randomized phase 3 OptiTROP-Breast03 trial
一线芦康沙妥珠单抗(sac-TMT)对比化疗用于PD-L1 CPS<10或既往早期阶段接受过PD-(L)1治疗的不可切除复发或转移性三阴性乳腺癌(TNBC):随机3期OptiTROP-Breast03研究
讲者:范蕾(复旦大学附属肿瘤医院)
专场:Rapid Fire 3
时间:12月9日4:30 PM–5:30 PM CST
地点:Stars at Night 1-2
摘要号:RF3-1
Clinical validation of a multimodal model for frontline therapeutic selection in breast cancer
乳腺癌一线治疗选择的多模态模型临床验证
讲者:Luca Boscolo-Bielo, Memorial Sloan Kettering Cancer Center, New York, NY
摘要号:RF3-2
A single cell and spatial atlas of preinvasive breast cancer
浸润前乳腺癌的单细胞与空间图谱
讲者:Aatish Thennavan, UT MD Anderson Cancer Center, Houston, TX
摘要号:RF3-3
A Multi-cohort Comparison of Genomic, Clinical, and AI Models for Recurrence Prediction in Early Breast Cancer
早期乳腺癌复发预测的基因组、临床与AI模型的多队列比较
讲者:Lajos Pusztai, Yale University, New Haven, CT
摘要号:RF3-4
Validation of Quantitative Standardized High Sensitivity (HS)-HER2 as a prognostic factor for outcomes with trastuzumab deruxtecan (T-DXd) for metastatic breast cancer
验证定量标准化高灵敏度(HS)-HER2作为T-DXd治疗转移性乳腺癌预后因素的临床价值
讲者:Paolo Tarantino, Dana-Farber Cancer Institute, Boston, MA
摘要号:RF3-5
Pretreatment spatial transcriptomic features associated with response to neoadjuvant HER2-targeted therapy in HER2-positive breast cancer
HER2阳性乳腺癌中与新辅助HER2靶向治疗反应相关的治疗前空间转录组学特征
讲者:Emilia Morales, Karolinska Institutet, Stockholm, Sweden
摘要号:RF3-6
Artera Multimodal AI Digital Pathology Identifies Distant Metastasis and Late Recurrence Risk Beyond the Recurrence Score: External Validation in TAILORx
Artera多模态AI数字病理学在复发评分之外识别远处转移和晚期复发风险:TAILORx研究的外部验证
讲者:Rima Patel, Icahn School of Medicine at Mount Sinai, New York, NY
专场:Rapid Fire 4
时间:12月9日5:30 PM–6:30 PM CST
地点:Stars at Night 1-2
摘要号:RF4-1
Neoadjuvant Pembrolizumab or Placebo Plus Chemotherapy Followed by Adjuvant Pembrolizumab or Placebo for High-Risk, Early-Stage Triple-Negative Breast Cancer (TNBC): Final Analysis Results in the T2N0 Subgroup From the Phase 3 KEYNOTE-522 Study
高危早期三阴性乳腺癌(TNBC)新辅助帕博利珠单抗或安慰剂联合化疗,序贯辅助帕博利珠单抗或安慰剂治疗:3期KEYNOTE-522研究T2N0亚组的最终分析结果
讲者:Peter Schmid, Barts Cancer Institute, Queen Mary University London, London, United Kingdom
摘要号:RF4-2
Long-term outcomes after pathological complete response (pCR) to neoadjuvant chemo-immunotherapy (NA-CIO) without adjuvant PD-1/PD-L1 inhibition in early-stage triple negative breast cancer: an individual patient pooled analysis
早期三阴性乳腺癌新辅助化疗联合免疫治疗(NA-CIO)达到病理学完全缓解(pCR)后,未行辅助PD-1/PD-L1抑制剂治疗的长期结局:个体患者汇总分析
讲者:Stephen J Luen, Peter MacCallum Cancer Centre, Melbourne, Australia
摘要号:RF4-4
Efficacy and safety of bulumtatug fuvedotin (BFv, 9MW2821), a Nectin-4 antibody-drug conjugate (ADC), in patients with advanced triple-negative breast cancer (aTNBC) previously treated with antibody-drug conjugates (ADCs): a phase Ib dose optimization study (9MW2821-CP103).
Nectin-4抗体偶联药物(ADC)bulumtatug fuvedotin(BFv,9MW2821)在既往接受过ADC治疗的晚期三阴性乳腺癌(aTNBC)患者中的疗效与安全性:一项Ib期剂量优化研究(9MW2821-CP103)
讲者:Nour Abuhadra, Memorial Sloan Kettering Cancer Center, New York, NY
摘要号:RF4-3
Whole-genome sequencing-defined homologous recombination deficiency predicts carboplatin benefit in early triple-negative breast cancer: long-term survival outcome and biomarker analysis of the phase III PEARLY trial (KCSG BR 15-1)
全基因组测序定义的同源重组修复缺陷预测早期三阴性乳腺癌卡铂获益:III期PEARLY研究(KCSG BR 15-1)的长期生存结局与生物标志物分析
讲者:Joohyuk Sohn, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea, Republic of
摘要号:RF4-5
Phase II Study of Izalontamab Brengitecan (iza-bren) Combined with Toripalimab in Patients with Unresectable Locally Advanced, Recurrent or Metastatic Triple-Negative Breast Cancer (TNBC)
伦康依隆妥单抗(iza-bren)联合特瑞普利单抗治疗不可切除的局部晚期、复发或转移性三阴性乳腺癌(TNBC)的II期研究
讲者:张剑(复旦大学附属肿瘤医院)
摘要号:RF4-6
Safety and preliminary efficacy of SYS6010 monotherapy in patients with HER2-negative, EGFR-expressing breast cancer
SYS6010单药治疗HER2阴性、EGFR表达乳腺癌患者的安全性与初步疗效
讲者:张剑(复旦大学附属肿瘤医院)