瞭望前瞻丨SABCS 2026会议首日(12月8日)重要内容速览!

第49届圣安东尼奥乳腺癌研讨会(SABCS 2026)将于当地时间2026年12月8-11日在美国得克萨斯州圣安东尼奥举行。作为乳腺癌领域的顶级盛会,SABCS聚焦乳腺癌生物学、病因、预防、诊断及治疗前沿,促进临床、转化与基础研究的深度融合,为全球科研人员提供交流协作与专业成长的平台。日前,SABCS官网已披露本届大会摘要标题。

编者按:第49届圣安东尼奥乳腺癌研讨会(SABCS 2026)将于当地时间2026年12月8-11日在美国得克萨斯州圣安东尼奥举行。作为乳腺癌领域的顶级盛会,SABCS聚焦乳腺癌生物学、病因、预防、诊断及治疗前沿,促进临床、转化与基础研究的深度融合,为全球科研人员提供交流协作与专业成长的平台。日前,SABCS官网已披露本届大会摘要标题。

肿瘤瞭望特整理会议首日(12月8日)精彩内容,涵盖研讨会、职业发展论坛、特别会议、教育专场及Mini口头报告等,并将Mini口头报告(Rapid Fire 1和Rapid Fire 2)摘要题目进行整理,以便读者快速了解会议动态,敬请关注后续详细报道!

四场研讨会:1、研讨会3:真实世界临床试验设计基础;2、研讨会4:临床AI工具的实践应用;3、研讨会1:超越动物模型-乳腺癌研究的新型替代方法;4、研讨会2:基于人工智能的病理学进展。

四场职业发展论坛:1、肿瘤学职业的未来保障:应对新规则的崭新指南;2、迈向成功;3、迈向成功:STEM领域女性的抱负与可持续职业发展;4、职业发展:论文发表入门课。

四场特别会议:1、特别会议1:将生活方式医学融入乳腺癌诊疗-科学、策略与技能;2、特别会议2:利用免疫系统预防乳腺癌-新兴疫苗;3、特别会议3:乳腺癌的全球视角——从人群风险到精准诊疗;4、特别会议9:现代减肥药物与乳腺癌。

六场教育专场:1、教育专场1:转移性乳腺癌中的生物标志物指导的精准治疗;2、教育专场2:新疗法=新毒性;3、教育专场3:遗传风险与筛查。4、教育专场4:器官特异性转移与全身免疫之间的相互作用;5、教育专场5:浸润性乳腺癌手术范式的选择性消除;6、教育专场6:靶向乳腺癌表观基因组。

两场Mini口头报告:1、Rapid Fire 1;2、Rapid Fire 2。

专场:Rapid Fire 1

时间:12月8日 4:30 PM-5:30 PM CST

地点:Stars at Night 1-2

摘要号:RF1-1

Zanidatamab as a component of neoadjuvant therapy in HER2+ breast cancer: results from the I-SPY2.2 trial

Zanidatamab是HER2阳性乳腺癌新辅助治疗的组成部分:I-SPY2.2研究结果

讲者:Anthony D Elias, University of Colorado, Aurora, CO

摘要号:RF1-2

Event-free survival from the randomized phase 2 neohip trial evaluating neoadjuvant taxane, her2-targeted therapy, +/- pembrolizumab in early-stage her2-positive breast cancer

评估早期HER2阳性乳腺癌新辅助紫杉烷类、HER2靶向治疗联合/不联合帕博利珠单抗的随机2期neoHIP试验的无事件生存期

讲者:Heather L McArthur, UTSW, Dallas, TX

摘要号:RF1-3

Circulating tumor DNA (ctDNA) dynamics and pathological complete response (pCR) in high-risk HER2+ early breast cancer (eBC) treated with neoadjuvant trastuzumab deruxtecan followed by paclitaxel + trastuzumab + pertuzumab (T-DXd-THP) vs dose-dense doxorubicin + cyclophosphamide followed by THP (ddAC-THP): A DESTINY-Breast11 (DB-11) analysis

高危HER2阳性早期乳腺癌(eBC)接受新辅助T-DXd序贯紫杉醇+曲妥珠单抗+帕妥珠单抗(T-DXd-THP)对比剂量密集多柔比星+环磷酰胺序贯THP(ddAC-THP)治疗中的循环肿瘤DNA(ctDNA)动态变化与病理完全缓解(pCR):DESTINY-Breast11 (DB-11) 分析

讲者:Shanu Modi, Memorial Sloan Kettering Cancer Center, New York, NY

摘要号:RF1-4

Optimising the duration of trastuzumab in early-stage HER2-positive breast cancer – an Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) meta-analysis

优化早期HER2阳性乳腺癌中曲妥珠单抗的治疗持续时间——早期乳腺癌试验协作组(EBCTCG)荟萃分析

讲者:Rosie Bradley, University of Oxford, Oxford, United Kingdom

摘要号:RF1-5

A randomized trial of trastuzumab deruxtecan and biology-driven selection of neoadjuvant treatment for HER2-positive breast cancer: First analysis of the ARIADNE trial

T-DXd及基于生物学驱动的新辅助治疗选择在HER2阳性乳腺癌中的随机试验:ARIADNE研究的首次分析

讲者:Theodoros Foukakis, Karolinska Institute, Stockholm, Sweden

摘要号:RF1-6

Patina (aft-38): palbociclib benefit across key prespecified subgroups in hr+/her2-positive advanced breast cancer – final protocol-specified pfs analysis

PATINA (AFT-38):哌柏西利在HR+/HER2+晚期乳腺癌关键预设亚组中的获益——最终方案规定的无进展生存期(PFS)分析

讲者:Otto Metzger, Dana-Farber Cancer Institute, Boston, MA

摘要号:RF1-7

The STOP-HER2 Trial: A Phase 2 Study of Stopping Trastuzumab – Outcomes in Patients with HER2+ Metastatic Breast Cancer (MBC) (TBCRC 062)

STOP-HER2研究:停止曲妥珠单抗治疗的2期研究——HER2阳性转移性乳腺癌(MBC)患者的结局(TBCRC 062)

讲者:Heather A Parsons, Fred Hutchinson Cancer Center, Seattle, WA

专场:Rapid Fire 2

时间:5:30 PM–6:30 PM CST

地点:Stars at Night 1-2

摘要号:RF2-1

Updated Overall Survival (OS) Analysis from the Phase 3 ASCENT-07 Study of Sacituzumab Govitecan in Participants with HR+/HER2- Inoperable, Locally Advanced, or Metastatic Breast Cancer Post Endocrine Therapy

3期ASCENT-07研究更新总生存期(OS)分析:戈沙妥珠单抗用于内分泌治疗后HR+/HER2-不可手术、局部晚期或转移性乳腺癌患者

讲者:Hope S Rugo, City of Hope Comprehensive Cancer Center, Duarte, CA

摘要号:RF2-2

Prognostic and predictive value of key immunohistochemistry (IHC) protein biomarker expression levels in the NATALEE trial of adjuvant ribociclib (RIB) and nonsteroidal aromatase inhibitor (NSAI) in hormone receptor-positive/human epidermal growth factor receptor 2−negative early breast cancer (HR+/HER2− EBC)

NATALEE研究中关键免疫组化(IHC)蛋白生物标志物表达水平的预后与预测价值:辅助瑞波西利(RIB)联合非甾体芳香化酶抑制剂(NSAI)治疗激素受体阳性/人表皮生长因子受体2阴性早期乳腺癌(HR+/HER2− EBC)

讲者:Michael Press, USC, Los Angeles, CA

摘要号:RF2-3

h&E-derived gene-expression multimodal multitask modeling predicts chemotherapy benefit, distant recurrence risk, and 21-gene recurrence score in tailorx

基于H&E染色衍生基因表达的多模态多任务模型预测TAILORx试验中的化疗获益、远处复发风险及21基因复发评分

讲者:Joseph Sparano, Icahn School of Medicine at Mount Sinai, New York, CA

摘要号:RF2-4

Genomic Response-Guided Chemotherapy Omission After Neoadjuvant Ribociclib and Endocrine Therapy in High-Risk HR+/HER2− Early Breast Cancer: Updated Results from the Phase II SOLTI-UNICANCER RIBOLARIS Trial

高危HR+/HER2-早期乳腺癌新辅助瑞波西利联合内分泌治疗后基于基因组应答指导的化疗豁免:II期SOLTI-UNICANCER RIBOLARIS研究的更新结果

讲者:Milana Arantza Bergamino Sirvén, Hospital Clinic de Barcelona// SOLTI// IDIBAPS, Barcelona, Spain

摘要号:RF2-5

Prospective Validation of Modified PEPI Following Neoadjuvant (Neoadj) Anastrozole (ANA): Five-Year (5y) Recurrence-free Survival (RFS) from Alliance A011106 (ALTERNATE)

新辅助阿那曲唑(ANA)治疗后改良PEPI的前瞻性验证:Alliance A011106(ALTERNATE)研究的5年无复发生存期(RFS)

讲者:Cynthia X Ma, Washington University in St. Louis, Saint Louis, MO

摘要号:RF2-6

Cdk2 mediates RB-independent entry into S phase and is a therapeutic target in ER+/RB-deficient, CDK4/6 inhibitor-resistant breast cancer

Cdk2介导rb非依赖性进入S期,是ER+/ RB缺陷、CDK4/6抑制剂耐药乳腺癌的治疗靶点

讲者:Chang-Ching A Lin, UT Southwestern Medical Center, Dallas, TX

摘要号:RF2-7

Results from KEYNOTE-B49: a phase 3, randomized, double-blind study of pembrolizumab (vs placebo) plus chemotherapy in participants with HR+/HER2− locally recurrent inoperable or metastatic breast cancer

KEYNOTE-B49研究结果:帕博利珠单抗(对比安慰剂)联合化疗治疗HR+/HER2-局部复发不可手术或转移性乳腺癌的3期、随机、双盲研究

讲者:Peter Schmid, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

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